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The metformin PMP trial at the University of California, Irvine is testing whether people with pseudomyxoma peritonei can take 850 mg of metformin a day for up to 18 months. It is a small, single-site study, and the main question right now is tolerability, not whether tumors shrink. Members started asking about this trial within…
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Short answer: On August 26, 2026, the FDA approved Rasonque (daraxonrasib), the first RAS drug approved for pancreatic cancer and the first that blocks multiple mutant forms of RAS at once. The approval covers metastatic pancreatic adenocarcinoma only. There is no approved RAS inhibitor appendix cancer patients can get today. The FDA just approved the…
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Short answer: Bowel obstruction after HIPEC is a recognized complication of cytoreductive surgery and heated intraperitoneal chemotherapy. Studies have documented hospital readmissions for small bowel obstruction months and even years after surgery. What those studies may miss are the episodes patients manage entirely at home, without an emergency department visit or an admission. This started…
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Christine Hill has lived with signet ring cell appendix cancer since 2021. This is her story of six surgeries, two ostomy bags, a tumor whose molecular profile changed over time, and a decision she makes every single day to keep living. Christine and I met early in my appendix cancer journey, during a Saturday PMP…
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A 71-year-old man with stage IV appendiceal mucinous adenocarcinoma remained recurrence-free for ten years, even though he never had HIPEC. His case is a reminder that survival is shaped by more than stage alone. Tumor biology, treatment decisions, and response to therapy all matter. I read a lot of case reports. Most of them I…
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A new pathology study found a treatment target, a protein called Claudin 18.2, on some high-grade appendiceal mucinous carcinoma tissue. That same protein is the target of an FDA-approved drug for certain stomach and gastroesophageal cancers. This does not mean that drug works for appendix cancer. It means there is now a reason to look.…